Research to fight against Crohn’s disease is increasing. If we manage today to reduce the symptoms, there is still no real cure. Not discouraged, scientists are now experimenting with the effects of cannabinoids on Inflammatory Bowel Disease; Crohn’s Disease and the “Cannabis Decryption”. This article looks at gastrointestinal conditions and their associated symptoms that could be improved with medicinal cannabis.

If the legalization of therapeutic cannabis raises questions from a political point of view, it seems that the medical approach today has many advantages, specifically for the treatment of various diseases.This especially being the case for inflammatory bowel diseases, or IBD, which includes Crohn’s disease or ulcerative colitis, where medical cannabis has shown a reduction in symptoms. American scientists have managed, in a new study published in the Journal of Clinical Investigation, to demonstrate how cannabis works to reduce the symptoms of IBD.

After conducting a series of experiments in mice, the researchers found that intestinal inflammation was regulated by two essential processes, continually changing and balanced according to the intestinal environment. The first process promotes an aggressive immune response in the gut to destroy dangerous pathogens, but can also damage the intestinal lining when immune cells attack without differentiating healthy cell pathogens. The second process, described for the first time in this study, disables the inflammatory response through specific molecules transported through the epithelial cells lining the intestinal wall. And it turns out that this answer requires a natural molecule called endocannabinoid, very close to the particles of cannabinoids naturally present in cannabis. In theory, cannabis use would allow the cannabinoids of the plant to regulate intestinal inflammation so that it is neither too aggressive nor too weak, like the endocannabinoids that our body produces naturally.

However, scientists remain very cautious: ” We must be clear that if this is a plausible explanation of why marijuana users have reported that cannabis relieves the symptoms of IBD, so far we have only evaluated this in mice, and have not proved this experimentally in humans. We hope, however, that these findings will help us develop new ways to treat inflammatory bowel disease in humans,” concluded Professor Randy Mrsny of the Department of Pharmacy and Pharmacology at the University of Bath.


Significant Medicinal Uses of Cannabis:

The list of conditions that cannabis is supposed to treat or cure is very long and continues to grow, but research is still lacking in many areas. This is largely because cannabis has been both stigmatized and illegal in most parts of the world since the last century. Threrfore, research could intensify as legalization becomes more commonplace. This is complicated by the fact that it is difficult for researchers to conduct double-blind clinical trials on most cannabis products, since subjects may be able to determine whether they are given active therapy or placebo. However, current research indicates that certain conditions may be clinically improved by cannabis use, including inflammatory bowel disease, multiple sclerosis, neuropathic pain, nausea and vomiting to cancer or chemotherapy, pediatric seizure disorders and a wide variety of other diseases or conditions.

Some research suggests that the SEC may play a role in intestinal health. In particular, inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, may be partially influenced by SEC changes, since this system may be able to modulate inflammatory responses. Research also indicates that anandamide levels, an endocannabinoid, are significantly lower in the inflamed intestinal mucosa of people with IBD than in those with healthy intestinal tissue. Early effects research Cannabis use to treat IBD is very promising, but there is still a long way to go before definitively claiming that cannabis is an effective treatment for IBD.

In a retrospective study, researchers surveyed 30 Israeli Crohn’s patients about the severity of their symptoms before and after using cannabis and noted significant improvements. They found that 70% of patients experienced a reduction in the severity of Crohn’s symptoms when they ate cannabis, and that many were able to reduce or eliminate the medications they took. For example, before using cannabis, each person took any prescription medication to treat their disease. By using cannabis, nine people were able to stop using all of their prescription medications. They also reported a reduction in individual daily bowel movements from eight to five, as well as a slight decrease in the number of surgical procedures required.


Crohn’s Disease and Cannabis: the Four Major Benefits!
  • Anti-inflammatory Effect

Clinical trials have shown that cannabinoids act on the CB2 receptor. Indeed, a reduction of the inflammation associated with CB2 has been noted. And our gut contains cannabinoid receptors, people with IBD have a concentration of CB2 well above normal. Hence a potential therapeutic benefit for treating IBD.

These include CBD and delta-9 THC, active substances of the plant, which reduce the inflammation of the receptors. As a reminder, THC is a psychoactive substance that is, one can giggle and overflow with imagination. However, CBD has no psychoactive effects. If the first is illegal in France and classified as narcotic, the CBD is perfectly legal.

  • An Analgesic  \ˌa-nᵊl-ˈjē-zik, -sik\

Very often, people with Crohn’s disease live with severe chronic pain. Thus, being often the result of inflammation, CBD and delta-9 THC could provide considerable relief on a daily basis. Also, a pilot study by inhalation of cannabis wished to demonstrate the different perceptions of the symptoms before and after consumption. And pain, previously assessed at 6.5 out of 10 (personal scale) in patients in this study, was only 2 out of 10 after cannabis use.

Other non-inhalation studies are conducted. And if the mechanisms of action of THC and CBD on pain are not fully understood, it seems that the pain-relieving effect of cannabinoids can be explained by combined impacts, such as anti-inflammatory, antinociceptive and antispasmodic effects.

  • Anti-diarrheal Medication

Diarrhea is also one of the most common symptoms of Crohn’s disease. This condition is linked, among other things, to the inflammation of the intestinal mucosa, increased secretion of fluids and – the presence of bacterial agents.

The cannabinoids have anti-bacterial properties and also reduce intestinal motility and secretion of fluids caused by inflammation. The said properties associated with cannabinoids, therefore, prevent diarrhea.

  • Stimulant of Ones Appetite

Another symptom associated with IBD is the loss of appetite. The California study evaluated patients ‘ appetite before and after cannabis use. From 1 in 10, the appetite has increased significantly to 7 out of 10. Because the use of cannabis prevents excessive peristalsis, which is the assimilation and digestion of food. It also increases hunger by stimulating ghrelin, a primary hormone that stimulates the human appetite.

Cannabis Link to Relieving Intestinal Inflammation Explained…

Published on Aug 14, 2018
University of Bath


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